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1

Multiparametric characterization by flow cytometry of flow-sorted subpopulations of a human hepatoma cell line useful for drug research

José-Enrique O'Connor, Alicia Martínez, José V. Castell, María-José Gómez-Lechón

Journal:

Cytometry Part A

Year:

2005

Language:

english

File:

PDF, 469 KB

english, 2005

2

Inhibition of human P450 enzymes by natural extracts used in traditional medicine

Idania Rodeiro, María T. Donato, Nuria Jimenez, Gabino Garrido, Jorge Molina-Torres, Roberto Menendez, José V. Castell, María J. Gómez-Lechón

Journal:

Phytotherapy Research

Year:

2009

Language:

english

File:

PDF, 236 KB

english, 2009

3

Measurement of intracellular LDH activity in 96-well cultures: A rapid and automated assay for cytotoxicity studies

Xavier Ponsoda, Ramiro Jover, José Vicente Castell, María José Gómez-Lechón

Journal:

Methods in Cell Science

Year:

1991

Language:

english

File:

PDF, 409 KB

english, 1991

4

Influence of branched-chain amino acid composition of culture media on the synthesis of plasma proteins by serum-free cultured rat hepatocytes

Angel Montoya, Maria J. Gómez-Lechón, Jose V. Castell

Journal:

In Vitro Cellular & Developmental Biology - Plant

Year:

1989

Language:

english

File:

PDF, 630 KB

english, 1989

5

Hepatocyte cell lines: their use, scope and limitations in drug metabolism studies

Castell, José V, Jover, Ramiro, Martínez-Jiménez, Celia P, Gómez-Lechón, María José

Journal:

Expert Opinion on Drug Metabolism & Toxicology

Year:

2006

Language:

english

File:

PDF, 476 KB

english, 2006

6

Inhibition of P450 Enzymes: An In Vitro Approach

Donato, Maria, Gomez-Lechon, Maria

Journal:

Current Enzyme Inhibition

Year:

2006

Language:

english

File:

PDF, 373 KB

english, 2006

7

Clinical Application of Pluripotent Stem Cells

Tolosa, Laia, Pareja, Eugenia, Gómez-Lechón, Maria José

Journal:

Transplantation Journal

Year:

2016

Language:

english

File:

PDF, 350 KB

english, 2016

8

Low density lipoprotein receptor-deficient hepatocytes differentiated from induced pluripotent stem cells allow familial Hypercholesterolemia modelling, CRISPR/Cas-mediated genetic correction, and productive hepatitis C virus infection

Caron, Jérôme, Péne, Véronique, Tolosa, L., Villaret, M., Luce, E., Fourrier, Angélique, Sami, S., Bruckert, E., Gómez-Lechón, María José, Nguyen, T.H., Rosenberg, A.R., Weber, A., Dubart-Kupperschmit

Journal:

Journal of Hepatology

Year:

2018

Language:

english

File:

PDF, 52 KB

english, 2018

9

Cytotoxic and Apoptotic Effects on Hepatocytes of Secondary Metabolites Obtained from Lichens

Correché, Estela Raquel, Enriz, Ricardo Daniel, Piovano, Marisa, Garbarino, Juan, Gómez-Lechón, María José

Journal:

Alternatives to laboratory animals : ATLA

Year:

2004

Language:

english

File:

PDF, 112 KB

english, 2004

10

Human Hepatic Cell Cultures: In Vitro and In Vivo Drug Metabolism

Gómez-Lechón, María José, Donato, Teresa, Ponsoda, Xavier, Castell, José V.

Journal:

Alternatives to laboratory animals : ATLA

Year:

2003

Language:

english

File:

PDF, 144 KB

english, 2003

11

Long-term expression of differentiated functions in hepatocytes cultured in three-dimensional collagen matrix

Maria José Gómez-Lechón, Ramiro Jover, Teresa Donato, Xavier Ponsoda, Cristina Rodriguez, Karsten G. Stenzel, Rainer Klocke, Dieter Paul, Isabel Guillén, Roque Bort, José V. Castell

Journal:

Journal of Cellular Physiology

Year:

1998

Language:

english

File:

PDF, 311 KB

english, 1998

12

Acute-phase response of human hepatocytes: Regulation of acute-phase protein synthesis by interleukin-6

José V. Castell, Maria José Gómez-lechón, Martina David, Ricardo Fabra, Ramón Trullenque, Prof. Dr. Peter C. Heinrich

Journal:

Year:

1990

Language:

english

File:

PDF, 881 KB

english, 1990

13

Effects of hepatocyte growth factor on the growth and metabolism of human hepatocytes in primary culture

María José Gómez-Lechón, José Castelli, Isabel Guillén, Enrique o'Connor, Toshikazu Nakamura, Ricardo Fabra, Ramón Trullenque

Journal:

Year:

1995

Language:

english

File:

PDF, 836 KB

english, 1995

14

Intracellular glutathione in human hepatocytes incubated with S-adenosyl-L-methionine and GSH-depleting drugs

Xavier Ponsoda, Ramiro Jover, María José Gómez-Lechón, Ricardo Fabra, Ramón Trullenque, JoséV. Castell

Journal:

Year:

1991

Language:

english

File:

PDF, 594 KB

english, 1991

15

Evaluation of ketoprofen (R, S and RS) phototoxicity by a battery of in vitro assays

Francisco Boscá, Germano Carganico, JoséV. Castell, Maria J. Gómez-Lechón, Daniel Hernandez, David Mauleón, Luis A. Martínez, Miguel A. Miranda

Journal:

Journal of Photochemistry and Photobiology B: Biology

Year:

1995

Language:

english

File:

PDF, 524 KB

english, 1995

16

Expression and induction of a large set of drug-metabolizing enzymes by the highly differentiated human hepatoma cell line BC2

María J. Gómez-Lechón, Teresa Donato, Ramiro Jover, Cristina Rodriguez, Xavier Ponsoda, Denize Glaise, José V. Castell, Christiane Guguen-Guillouzo

Journal:

Year:

2001

Language:

english

File:

PDF, 1.32 MB

english, 2001

17

A new in vitro approach for the simultaneous determination of phase I and phase II enzymatic activities of human hepatocyte preparations

Agustín Lahoz, Maria Teresa Donato, Sandra Montero, José V. Castell, Maria José Gómez-Lechón

Journal:

Rapid Communications in Mass Spectrometry

Year:

2008

Language:

english

File:

PDF, 144 KB

english, 2008

18

Effect of dexamethasone on the isozyme pattern of adult rat liver parenchymal cells in primary cultures

Juan Emilio Felíu, Julio Coloma, María-José Gómez-Lechón, María Dolores García, José Báguena

Journal:

Molecular and Cellular Biochemistry

Year:

1982

Language:

english

File:

PDF, 780 KB

english, 1982

19

Characteristics of arachidonic acid metabolism of human endothelial cells in culture

Vincenta Martinez-Sales, Maria José Gomez-Lechón, Juan Gilabert

Journal:

Year:

1990

Language:

english

File:

PDF, 1.04 MB

english, 1990

20

Diclofenac sodium and cyclosporin A inhibit human lens epithelial cell proliferation in culture

Pedro Cortina, Maria José Gómez-Lechón, Amparo Navea, José Luis Menezo, Maria Carmen Terencio, Manuel Diaz-Llopis

Journal:

Graefe's Archive for Clinical and Experimental Ophthalmology

Year:

1997

Language:

english

File:

PDF, 613 KB

english, 1997

21

Photobinding of Tiaprofenic Acid and Suprofen to Proteins and Cells: A Combined Study Using Radiolabeling, Antibodies and Laser Flash Photolysis of Model Bichromophores

José V. Castell, Daniel Hernández, María José Gómez-Lechón, Agustín Lahoz, Miguel A. Miranda, Isabel M. Morera, Julia Perez-Prieto, Zaideth Sarabia

Journal:

Photochemistry and Photobiology

Year:

1998

Language:

english

File:

PDF, 918 KB

english, 1998

22

Chronic Ethanol Consumption Enhances Interleukin-1-Mediated Signal Transduction in Rat Liver and in Cultured Hepatocytes

Soraya L. Valles, Ana M. Blanco, Inmaculada Azorin, Rosa Guasch, María Pascual, María Jose Gomez-Lechon, Jaime Renau-Piqueras, Consuelo Guerri

Journal:

Alcoholism: Clinical and Experimental Research

Year:

2003

Language:

english

File:

PDF, 2.32 MB

english, 2003

23

Diagnosis of malignant ascites

Martín Prieto, María José Gómez-Lechón, Melchor Hoyos, Jose V. Castell, Domingo Carrasco, Joaquín Berenguer

Journal:

Digestive Diseases and Sciences

Year:

1988

Language:

english

File:

PDF, 483 KB

english, 1988

24

A human hepatocellular in vitro model to investigate steatosis

María José Gómez-Lechón, María Teresa Donato, Alicia Martínez-Romero, Nuria Jiménez, José Vicente Castell, José-Enrique O’Connor

Journal:

Chemico-Biological Interactions

Year:

2007

Language:

english

File:

PDF, 595 KB

english, 2007

25

Hepatocytes—the choice to investigate drug metabolism and toxicity in man: In vitro variability as a reflection of in vivo

María José Gómez-Lechón, José Vicente Castell, María Teresa Donato

Journal:

Chemico-Biological Interactions

Year:

2007

Language:

english

File:

PDF, 1.17 MB

english, 2007

26

Activities of Spanish network for alternatives (REMA) in promoting animal alternatives

Argelia Castaño, Jose V. Castell, María J. Gomez-Lechon, Francisco Ferrandiz, Adela Lopez de Cerain, Eduardo De la Peña, Pilar Prieto, Guillermo Repetto, Joan A. Vericat, Eugenio Vilanova

Journal:

Comparative Biochemistry and Physiology Part A: Molecular & Integrative Physiology

Year:

2009

Language:

english

File:

PDF, 69 KB

english, 2009

27

Metabolism and bioactivation of toxicants in the lung. The in vitro cellular approach

José V. Castell, M. Teresa Donato, María José Gómez-Lechón

Journal:

Experimental and Toxicologic Pathology

Year:

2005

Language:

english

File:

PDF, 343 KB

english, 2005

28

Preclinical evaluation of drug—drug interaction potential: present status of the application of primary human hepatocytes in the evaluation of cytochrome P450 induction

Albert P. Li, Patrick Maurel, Maria Jose Gomez-Lechon, Larry C. Cheng, Malle Jurima-Romet

Journal:

Chemico-Biological Interactions

Year:

1997

Language:

english

File:

PDF, 913 KB

english, 1997

29

INVOLVEMENT OF DRUG-DERIVED PEROXIDES IN THE PHOTOTOXICITY OF NAPROXEN and TIAPROFENIC ACID

Jose V. Castell, Maria J. Gomez-Lechon, Carmina Grassa, Luis A. Martinez, Miguel A. Miranda, Pilar Tarrega

Journal:

Photochemistry and Photobiology

Year:

1993

Language:

english

File:

PDF, 666 KB

english, 1993

30

PHOTODYNAMIC LIPID PEROXIDATION BY THE PHOTOSENSITIZING NONSTEROIDAL ANTIINFLAMMATORY DRUGS SUPROFEN AND TIAPROFENIC ACID

Jose V. Castell, Maria J. Gomez-Lechon, Carmina Grassa, Luis A. Martinez, Miguel A. Miranda, Pilar Tarrega

Journal:

Photochemistry and Photobiology

Year:

1994

Language:

english

File:

PDF, 509 KB

english, 1994

31

MOLECULAR BASIS OF DRUG PHOTOTOXICITY: PHOTOSENSITIZED CELL DAMAGE BY THE MAJOR PHOTOPRODUCT OF TIAPROFENIC ACID

Jose V. Castell, Maria J. Gomez-Lechon, Daniel Hernandez, Luis A. Martinez, Miguel A. Miranda

Journal:

Photochemistry and Photobiology

Year:

1994

Language:

english

File:

PDF, 464 KB

english, 1994

32

Quantitative RT-PCR Measurement of Human Cytochrome P-450s: Application to Drug Induction Studies

Cristina Rodrı&amp, #x0301, guez-Antona, Ramiro Jover, Maria-José Gómez-Lechón, José V. Castell

Journal:

Archives of Biochemistry and Biophysics

Year:

2000

Language:

english

File:

PDF, 287 KB

english, 2000

33

Cytochrome P-450 mRNA Expression in Human Liver and Its Relationship with Enzyme Activity

Cristina Rodrı&amp, #x0301, guez-Antona, M.Teresa Donato, Eugenia Pareja, Maria-José Gómez-Lechón, José V. Castell

Journal:

Archives of Biochemistry and Biophysics

Year:

2001

Language:

english

File:

PDF, 110 KB

english, 2001

34

Recombinant human interleukin-6 (IL-6/BSF-2/HSF) regulates the synthesis of acute phase proteins in human hepatocytes

José V. Castell, Maria J. Gómez-Lechón, Martina David, Toshio Hirano, Tadamitsu Kishimoto, Peter C. Heinrich

Journal:

Year:

1988

Language:

english

File:

PDF, 705 KB

english, 1988

35

Interleukin-6 is the major regulator of acute phase protein synthesis in adult human hepatocytes

José V. Castell, Maria J. Gómez-Lechón, Martina David, Tilo Andus, Thomas Geiger, Ramón Trullenque, Ricardo Fabra, Peter C. Heinrich

Journal:

Year:

1989

Language:

english

File:

PDF, 315 KB

english, 1989

36

Overexpression of SND p102, a rat homologue of p100 coactivator, promotes the secretion of lipoprotein phospholipids in primary hepatocytes

Lourdes Palacios, Begoña Ochoa, María José Gómez-Lechón, José Vicente Castell, Olatz Fresnedo

Journal:

Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids

Year:

2006

Language:

english

File:

PDF, 417 KB

english, 2006

37

Transcription factors involved in the expression of SLC28 genes in human liver parenchymal cells

Sonia Fernández-Veledo, Ramiro Jover, F. Javier Casado, Maria J. Gómez-Lechón, Marçal Pastor-Anglada

Journal:

Biochemical and Biophysical Research Communications

Year:

2007

Language:

english

File:

PDF, 415 KB

english, 2007

38

Mechanism-based selection of compounds for the development of innovative in vitro approaches to hepatotoxicity studies in the LIINTOP project

María José Gómez-Lechón, Laia Tolosa, José V. Castell, María Teresa Donato

Journal:

Toxicology in Vitro

Year:

2010

Language:

english

File:

PDF, 284 KB

english, 2010

39

Hepatocyte growth factor/scatter factor (HGF/SF) signals via the STAT3/APRF transcription factor in human hepatoma cells and hepatocytes

Fred Schaper, Elmar Siewert, Maria José Gómez-Lechón, Petros Gatsios, Martin Sachs, Walter Birchmeier, Peter C Heinrich, José Castell

Journal:

Year:

1997

Language:

english

File:

PDF, 543 KB

english, 1997

40

Semi-automatic quantitative RT-PCR to measure CYP induction by drugs in human hepatocytes

Gabriela Pérez, Beatriz Tabares, Ramiro Jover, Maria-José Gómez-Lechón, José V. Castell

Journal:

Toxicology in Vitro

Year:

2003

Language:

english

File:

PDF, 350 KB

english, 2003

41

Modulation of biotransformation and elimination systems by BM-21, an aqueous ethanolic extract from Thalassia testudinum, and thalassiolin B on human hepatocytes

Idania Rodeiro, Maria José Gómez-Lechón, Laia Tolosa, Gabriela Perez, Ivones Hernandez, Roberto Menendez, Erick Luis Regalado, José Vicente Castell, Maria Teresa Donato

Journal:

Journal of Functional Foods

Year:

2012

Language:

english

File:

PDF, 431 KB

english, 2012

42

Optimisation and pre-validation of an in vitro test strategy for predicting human acute toxicity: Progress of the “A-Cute-Tox” project

Agnieszka Kinsner-Ovaskainen, Cecilia Clemedson, Thomas Cole, Richard Clothier, Sandra Coecke, José-Enrique O’Connor, Bas Blaauboer, Maria-José Gómez-Lechón, Joan-Albert Vericat, Anna Forsby, Michael

Journal:

Toxicology Letters

Year:

2007

Language:

english

File:

PDF, 70 KB

english, 2007

43

Células madre del tejido adiposo: plasticidad hepática

Ana Bonora-Centelles, José Vicente Castell, María José Gómez-Lechón

Journal:

Gastroenterología y Hepatología

Year:

2008

File:

PDF, 173 KB

2008

44

In Vitro Methods in Pharmaceutical Research || Isolation, Culture and Use of Human Hepatocytes in Drug Research

Gómez-Lechón, María José

Year:

1996

Language:

english

File:

PDF, 3.20 MB

english, 1996

45

RENAL TUBERCULOSIS.

Cortina, Pedro, Jose Gomez-Lechon, Maria, Navea, Amparo, Menezo, Jose Luis

Journal:

Year:

1926

Language:

english

File:

PDF, 357 KB

english, 1926

46

In Vitro Test of Intraocular Lens Biocompatibility

Cortina, Pedro, Jose Gomez-Lechon, Maria, Navea, Amparo, Menezo, Jose Luis

Journal:

Journal of Cataract & Refractive Surgery

Year:

1995

Language:

english

File:

PDF, 270 KB

english, 1995

47

Influence of Branched-Chain Amino Acid Composition of Culture Media on the Synthesis of Plasma Proteins by Serum-Free Cultured Rat Hepatocytes

Angel Montoya, Maria J. Gómez-Lechón and Jose V. Castell

Journal:

In Vitro Cellular & Developmental Biology

Year:

1989

Language:

english

File:

PDF, 1.27 MB

english, 1989

48

Drug-Photosensitized Protein Modification: Identification of the Reactive Sites and Elucidation of the Reaction Mechanisms with Tiaprofenic Acid/Albumin as Model System †

Miranda, Miguel A., Castell, José V., Hernández, Daniel, Gómez-Lechón, María J., Bosca, Francisco, Morera, Isabel M., Sarabia, Zaideth

Journal:

Chemical Research in Toxicology

Year:

1998

Language:

english

File:

PDF, 119 KB

english, 1998

49

An update on metabolism studies using human hepatocytes in primary culture

Gómez-Lechón, María José, Castell, José V, Donato, María Teresa

Journal:

Expert Opinion on Drug Metabolism & Toxicology

Year:

2008

Language:

english

File:

PDF, 440 KB

english, 2008

50

Effect of Glucocorticoids on the Expression of γ-Glutamyltransferase and Tyrosine Aminotransferase in Serum-Free-Cultured Hepatocytes

GÓMEZ-LECHÓN, María José, GARCÍA, María Dolores, CASTELL, José Vicente

Journal:

Hoppe-Seyler's Zeitschrift für physiologische Chemie

Year:

1983

Language:

english

File:

PDF, 907 KB

english, 1983

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